Nowadays, the rapid development of science and technology is felt in various sectors, including nutrition and health. The concept of a medical paradigm through a predictive, preventive, personal, and participatory approach can manage and support a specific health status for individuals. Personalized nutrition is a basic concept that shows everyone has a different metabolism, genetics, biochemistry, and microbiota that contribute to the body’s response to nutritional intake. Therefore, the concept of personalized nutrition applies multidisciplinary, such as nutrition, medicine, biology, epigenetics, and genomics to demonstrate the relationship of individual variation to a disease risk.